Changes in the pharmacodynamics and pharmacokinetics of psycholeptic drugs in radiation-sickness. Effect of X-ray radiation on pharmacodynamic activity of nitrazepam in animals

The anticonvulsive effect of nitrazepam was determined in animals exposed to a single 600 R radiation and the exploring activity of the animals was studied after nitrazepam administered during radiation sickness caused by this exposure. On the 1st day after exposure the activity, reducing effect was slightly weaker but on days 3rd and 6th this effect was significantly stronger. The anticonvulsant effect of nitrazepam on the 3rd day after exposure was significantly greater as compared with control animals, but on the 6th day no difference in the power of anticonvulsant activity between the two groups of animals was found. (author)