Published September 1988
| Version v1
Journal article
Synthesis of [3H]clozapine
- 1. Vanderbilt Univ., Nashville, TN (USA)
- 2. Hoffmann-La Roche, Inc., Nutley, NJ (USA). Chemical Research Dept.
Description
[3H]Clozapine was prepared with a specific activity of 9.9 Ci/mmol by reaction of 8-chloro-11-(methylthio)-5H-dibenzo[b,e][1,4]diazepine with an excess of [3H]N-methylpiperazine. The latter was prepared from N-methylpyrazinium bromide in ethanolic hydrogen chloride by reduction at room temperature with tritium over 5% rhodium on aluminum oxide. (author)
Additional details
Additional titles
- Augmented title (English)
- Antipsychotic drug
Publishing Information
- Journal Title
- Journal of Labelled Compounds and Radiopharmaceuticals
- Journal Volume
- 25
- Journal Issue
- 9
- Series
- J. Labelled Compd. Radiopharm.
- Journal Page Range
- 1027-1033
- ISSN
- 0362-4803
- CODEN
- JLCRD
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- United Kingdom
- INIS RN
- 20028832
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
- Descriptors DEI
- CHEMICAL PREPARATION; LABELLING; ORGANIC NITROGEN COMPOUNDS; PSYCHOTROPIC DRUGS; RADIOPHARMACEUTICALS; TRITIUM COMPOUNDS
- Descriptors DEC
- CENTRAL NERVOUS SYSTEM AGENTS; DRUGS; HYDROGEN COMPOUNDS; LABELLED COMPOUNDS; MATERIALS; ORGANIC COMPOUNDS; RADIOACTIVE MATERIALS; SYNTHESIS