The clinical analysis of blood lipid and plasma NT-proBNP, CTnⅠ and hs-CRP levels determined in patients with chronic heart failure

Objective: To measure the levels of blood lipid and plasma N-terminal pro-brain natriuretic peptide (NT-proBNP), cardiac troponin Ⅰ (CTnⅠ) and high sensitive C-reaction protein (hsCRP) in patients with chronic heart failure (CHF), and carry out clinical analysis. Methods: The blood lipid and plasma NT-proBNP, CTnⅠ and hs-CRP levels in 165 patients with CHF and 60 controls were analyzed by chemistry, fluorescent immunoassay and radioimmunoassay, and then the results were analyzed and compared. Results: The serum TC, TG, LDL-C and HDL-C levels in 165 patients with CHF were significantly lower than those of 60 controls (TC:t_Ⅱ = 2.214, P < 0.05; t_Ⅲ = 2.873, P < 0.01; t_Ⅳ = 3.146; P < 0.01; TG:t_Ⅱ = 2.167, P < 0.05; t_Ⅲ = 2.863, P < 0.01; t_Ⅳ = 3.063, P < 0.01; LDL-C:t_Ⅱ = 2.147, P < 0.05; t_Ⅲ = 2.056, P < 0.05; t_Ⅳ = 2.184, P < 0.05; HDL-C:t_Ⅱ = 2.137, P < 0.05; t_Ⅲ = 2.256, P < 0.05; t_Ⅳ = 3.148, P < 0.01). In biomarkers determining, the plasma NT-proBNP, CTnⅠ and hs-CRP levels in 165 patients with CHF were significantly higher than those of 60 controls (NT-proBNP:t_Ⅱ = 2.096, P > 0.05; t_Ⅲ = 2.813, P < 0.01; t_Ⅳ = 4.135, P < 0.001; CTnⅠ:t_Ⅱ = 2.736, P < 0.01; t_Ⅲ = 2.962, P < 0.01; t_Ⅳ = 3.816, P < 0.01 and hs-CRP:t_Ⅱ = 2.103, P < 0.05; t_Ⅲ = 2.956, P < 0.01; t_Ⅳ = 4.452, P < 0.001), and the plasma three biomarker levels were increased with decreasing left ventricular ejection function (LVEF). Conclusion: The blood lipid (TC, TG, LDL-C and HDL-C) levels were decreased with decreasing LVEF and showing abnormal metabolism, but the plasma biomarkers levels were increased with decreasing LVEF. (authors)