Published February 1997
| Version v1
Journal article
Synthesis of the monosodium salt of carbon-14 labeled paclitaxel (Taxol) 2'-ethyl carbonate 7-phosphonooxymethyl ether, a potential prodrug of paclitaxel
- 1. Bristol-Myers Squibb Co., Richard L. Gelb Center for Research and Development, Wallingford, CT (United States)
Description
The monosodium salt of carbon-14 labeled paclitaxel (Taxol) [N3'-14COPh] 2'-ethyl carbonate 7-phosphonooymethyl ether, was prepared from C-14 labeled paclitaxel [N3'-14COPh] in 5 steps. The radiochemical purity of the final product was greater than 99% and the specific activity was 25 μCi/mg. (author)
Additional details
Publishing Information
- Journal Title
- Journal of Labelled Compounds and Radiopharmaceuticals
- Journal Volume
- 39
- Journal Issue
- 2
- Journal Page Range
- p. 173-179.
- ISSN
- 0362-4803
- CODEN
- JLCRD4
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- United Kingdom
- INIS RN
- 29007160
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
- Descriptors DEI
- ANTINEOPLASTIC DRUGS; CARBON 14 COMPOUNDS; CHEMICAL PREPARATION; ETHERS; LABELLING; RADIOPHARMACEUTICALS; TERPENES
- Descriptors DEC
- CARBON COMPOUNDS; DRUGS; LABELLED COMPOUNDS; MATERIALS; ORGANIC COMPOUNDS; ORGANIC OXYGEN COMPOUNDS; RADIOACTIVE MATERIALS; SYNTHESIS