The progresses of mechanistic studies of the effect of NF-κB on radiation damage

The number of people needed to accept radiotherapy is increasing with the higher incidence of tumor, and the continuous development of radiation therapy technology has extended the long-term survival of patients. Avoiding the occurrence of radiation damage is particularly important. Since NF-κB plays an important role in gene transcription and regulation of radiation damage, this article introduced the structure, activation and function of NF-κB, reviewed the findings of NF-κB alterations in radiation injuries of brain and lung, and sketched the studies of NF-κB inhibitor. (authors)