Published 1976 | Version v1
Report Metadata-only

Influence of cysteamine on plasmatic amylase and S.G.O.T. activities in irradiated rats

Creators

  • 1. Centre de Recherches du Service de Sante des Armees, 92 - Clamart (France). Div. d'Hygiene Atomique

Description

Alterations in plasmatic amylase and SGOT (Serum Glutamic Oxalacetic Transaminase) activities were determined in rats after exposure to gamma radiation at two doses: 900 R (LD50/30) and 1200 R (LF100/30). These determinations were carried out 6 and 24 hours after irradiation. The rats were given intraperitoneal injection of cysteamine (100 mg/kg) 15 minutes before irradiation. A comparative study with non protected rats was performed. It was observed that plasmatic amylase activity was not affected either by irradiation or by cysteamine. Lethal or semi-lethal irradiation increased plasmatic SGOT activity. But no correlation was established between this increase and rat survival time

Abstract (French)

On a determine les alterations des activites de l'amylase et de la SGOT plasmatiques chez des rats exposes au rayonnement gamma a deux doses: 900 R (LD 50/30) et 1200 R (LD 100/30). Ces determinatons ont ete effectuees 6 h et 14 h apres l'irradiation. Les rats ont recu, 15 minutes avant l'irradiation, une injection de cysteamine par voie intraperitoneale, a la dose de 100 mg/kg. On a realise une etude comparative avec des rats non proteges. On a constate que l'activite de l'amylase plasmatique n'a ete influencee ni par l'irradiation, ni par la cysteamine. L'activite de la SGOT plasmatique a ete augmentee par l'irradiation delivree a dose letale ou semi-letale, mais cette augmentation n'a pas pu etre reliee au taux de survie

Additional details

Additional titles

Original title (French)
Influence de la cysteamine sur les activites de l'amylase et de la S.G.O.T. plasmatiques chez le rat irradie

Publishing Information

Imprint Title
1976 scientific works
Journal Page Range
p. 135-136.
Report number
CRSSA-RA--1976

INIS

Country of Publication
France
Country of Input or Organization
France
INIS RN
9414516
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Resource subtype / Literary indicator
Progress Report
Descriptors DEI
AMINO ACIDS; AMINOTRANSFERASES; BIOLOGICAL RADIATION EFFECTS; BLOOD PLASMA; CYSTAMINE; GAMMA RADIATION; LETHAL RADIATION DOSE; RADIOSENSITIVITY; RATS
Descriptors DEC
AMINES; ANIMALS; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BLOOD; BODY FLUIDS; CARBOXYLIC ACIDS; DRUGS; ELECTROMAGNETIC RADIATION; ENZYMES; IONIZING RADIATIONS; MAMMALS; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC SULFUR COMPOUNDS; RADIATION DOSES; RADIATION EFFECTS; RADIATIONS; RADIOPROTECTIVE SUBSTANCES; RESPONSE MODIFYING FACTORS; RODENTS; TRANSFERASES; VERTEBRATES

Optional Information

Notes
Imprint:Travaux scientifiques. Annee 1976.