Published 1978 | Version v1
Journal article Metadata-only

Intestinal tolerance in mice after low dose rate 60Co irradiation. Implications in radiotherapy

Creators

  • 1. Louvain Univ. (Belgium). Centre des Tumeurs

Description

Influence of absorbed dose rate has been studied in BALB/c mice for early intestinal tolerance. After selective abdominal irradiation, LD50 at 5.5 days increases from 12.36 to 20.22 and 21.79 Gy when dose rate decreases from 0.61 to 0.054 and 0.026 Gy/mn. LD50 at 6.5 days increases from 12.05 to 19.22 and 21.58 Gy respectively. The LD50 ratios are then 1.6 and 1.8 for both endpoints. After total body irradiation, LD50 at 5.5 days increases from 9.92 to 15.20 and 16.83 Gy when dose rate decreases from 0.56 to 0.049 and 0.024 Gy/mn. The corresponding LD50 ratios, i.e. 1.5 and 1.7 are then similar to the former ones. Increase of LD50 when decreasing dose rate is in agreement with that expected taking into account only repair of sublethal lesions, for the generally accepted cellular models

Abstract (French)

L'influence du debit de dose absorbee a ete etudiee chez la souris BALB/c pour la tolerance intestinale precoce. Apres irradiation abdominale selective, la DL50 a 5,5 jours augmente de 12,36 a 20,22 et 21,79 Gy lorsque le debit decroit de 0,61 a 0,054 et 0,026 Gy/mn. La DL50 a 6,5 jours croit de 12,05 a 19,22 et 21,58 Gy. Les rapports des DL50 sont donc de 1,6 et 1,8 pour les 2 criteres. Apres irradiation totale, la DL50 a 5,5 jours augmente de 9,92 a 15,20 et 16,83 Gy quand le debit decroit de 0,56 a 0,049 et a 0,024 Gy/mn, soit dans des rapports de 1,5 et 1,7 tres voisins des precedents. L'augmentation de la DL50 avec la diminution du debit est en accord avec celle attendue en tenant compte uniquement de la reparation des lesions subletales, pour les modeles cellulaires generalement admis

Additional details

Additional titles

Original title (French)
Tolerance de l'intestin de la souris a une irradiation par

Publishing Information

Journal Title
C. R. Seances Soc. Biol. Fil.
Journal Volume
172
Journal Issue
4
Series
C. R. Seances Soc. Biol. Fil.
Journal Page Range
774-778

INIS

Country of Publication
France
Country of Input or Organization
France
INIS RN
11521848
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
BIOLOGICAL RADIATION EFFECTS; DOSE RATES; DOSE-RESPONSE RELATIONSHIPS; GAMMA RADIATION; INTESTINES; LOW DOSE IRRADIATION; MICE; PARTIAL BODY IRRADIATION; SURVIVAL CURVES; WHOLE-BODY IRRADIATION
Descriptors DEC
ANIMALS; BIOLOGICAL EFFECTS; BODY; DIGESTIVE SYSTEM; ELECTROMAGNETIC RADIATION; EXTERNAL IRRADIATION; GASTROINTESTINAL TRACT; IONIZING RADIATIONS; IRRADIATION; MAMMALS; ORGANS; RADIATION EFFECTS; RADIATIONS; RODENTS; VERTEBRATES