Published January 2002 | Version v1
Journal article Metadata-only

Synthesis of 14C labelled lidocaine (α-diethylamino acet-2,6-dimethylanilide)

Creators

  • 1. Academia Sinica, Shanghai (China). Shanghai Inst. of Nuclear Research

Description

14C-lidocaine was composed by 14C-diethylamine reaction with ω-chloroacetic-2,6-dimethylaniline. 14C-diethylamine was prepared from Ba14CO3 via K14CN and 14C-acetonitrile which was hydrogenated. Radiochemical purity of 14C-diethylamine and 14C-lidocaine is >99% by HPLC and TLC respectively. 14C-lidocaine is needed for breath assay of mouse for measuring liver function

Additional details

Publishing Information

Journal Title
Nuclear Techniques
Journal Volume
25
Journal Issue
1
Journal Page Range
p. 54-56
ISSN
0253-3219

INIS

Country of Publication
China
Country of Input or Organization
China
INIS RN
33024843
Subject category
S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
Descriptors DEI
BIOLOGICAL FUNCTIONS; BREATH; CARBON 14; IMPURITIES; LABELLED COMPOUNDS; LIVER; SYNTHESIS
Descriptors DEC
BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CARBON ISOTOPES; DIGESTIVE SYSTEM; EVEN-EVEN NUCLEI; GLANDS; ISOTOPES; LIGHT NUCLEI; NUCLEI; ORGANS; RADIOISOTOPES; YEARS LIVING RADIOISOTOPES