Published November 1993 | Version v1
Journal article Metadata-only

Study on the bifunctional chelate agents in 90Y labeled antibody. A comparison of 1-(p-isothiocyanato-benzyl) DTPA and cyclic DTPA anhydride

Creators

  • 1. Academia Sinica, Beijing, BJ (China). Inst. of Atomic Energy

Description

Two bifunctional chelate agents 1-(p-isothiocyanato-benzyl) DTPA (SCN-Bz-DTPA) and cyclic DTPA anhydride (CDTPA) are synthesized and conjugated with antibody, subsequently labeled with 90Y (Ac)3. There are differences in two chelates conjugated with antibodies and the radiochemical stability of the preparation in Vitro. The results show that SCN-Bz-DTPA is superior to CDTPA

Additional details

Publishing Information

Journal Title
Journal of Nuclear and Radiochemistry
Journal Volume
15
Journal Issue
4
Journal Page Range
p. 219-223.
ISSN
0253-9950
CODEN
HHHHDH

INIS

Country of Publication
China
Country of Input or Organization
China
INIS RN
26000188
Subject category
S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
Descriptors DEI
ANHYDRIDES; CHELATING AGENTS; CHEMICAL PREPARATION; DTPA; IN VITRO; LABELLED COMPOUNDS; LABELLING; MONOCLONAL ANTIBODIES; PH VALUE; STABILITY; YTTRIUM 90
Descriptors DEC
AMINO ACIDS; ANTIBODIES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CARBOXYLIC ACIDS; DAYS LIVING RADIOISOTOPES; DRUGS; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; NUCLEI; ODD-ODD NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; RADIOISOTOPES; RADIOPROTECTIVE SUBSTANCES; RESPONSE MODIFYING FACTORS; SYNTHESIS; YTTRIUM ISOTOPES