Application of nanobodies in molecular imaging

Nanobodies, which occur naturally in Camelidae animals, are the functional heavy chain antibodies without light chains. Having the relative properties of small size, high stability, good solubility and targeting effect, nanobodies have a great potential in PET and SPECT imaging for the diagnosis and treatment of diseases, such as tumor and infectious disease. Radio-labeled nanobodies might have potential to become the molecular imaging probes of the next generation. (authors)