Body and brain development following exposure to 60Co γ-irradiation during pregnancy in mice
- 1. Nagoya Univ. (Japan). Research Inst. of Environmental Medicine
Description
We studied the dose-response effects of γ-irradiation on the weight gains of the body and the brain in ICR mice exposed to various doses of 60Co γ-irradiation ranging from 0 to 1.5 Gy on day 13 of pregnancy (E13). We found that 0.5 Gy γ-irradiation caused a significant reduction in brain weight but not in body weight among 6-week-old mice. Higher doses (1.0, 1.5 Gy) seriously inhibited body and brain development, resulting in significantly low weights at 6 weeks of age. A significantly lower brain weight among fetuses exposed to 1.5 Gy was found as early as 24 hours after exposure, while significant reductions in the body weight of these same fetuses appeared 3 days after exposure. The effects of radiation on brain and body development were similar for both males and females. (author)
Additional details
Publishing Information
- Journal Title
- Environmental Medicine
- Journal Volume
- 38
- Journal Issue
- 2
- Journal Page Range
- p. 111-114.
- ISSN
- 0287-0517
- CODEN
- ENMEE9
INIS
- Country of Publication
- Japan
- Country of Input or Organization
- Japan
- INIS RN
- 26040579
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- BIOLOGICAL RADIATION EFFECTS; CEREBRUM; DOSE-RESPONSE RELATIONSHIPS; FETUSES; GAMMA RADIATION; GROWTH; MENTAL DISORDERS; MICE; PREGNANCY; PRENATAL IRRADIATION; RADIATION DOSES; WEIGHT
- Descriptors DEC
- ANIMALS; BIOLOGICAL EFFECTS; BODY; BRAIN; CENTRAL NERVOUS SYSTEM; DISEASES; ELECTROMAGNETIC RADIATION; IONIZING RADIATIONS; IRRADIATION; MAMMALS; NERVOUS SYSTEM; NERVOUS SYSTEM DISEASES; ORGANS; PRENATAL EXPOSURE; RADIATION EFFECTS; RADIATIONS; RODENTS; VERTEBRATES