Relationship between recurrent spontaneous abortion and anti-β2-glycoprotein I antibody

Objective: To explore the relationship between recurrent spontaneous abortion (RSA) and anti-β2- glycoprotein I (anti-β2-GP I) antibody. Methods: The levels of anti-β2-GP I antibody in serum from 81 RSA patients and 39 normal women were detected by ELISA. Results: The positive rate of anti-β2-GP I in RSA patients (42.0%) was obviously higher than that in normal women (7.7 %) (P<0.01); there was obvious difference of the positive rate of anti-β2-GP I IgG in statistics between RSA patients (40.8%) and normal women (7.7%) (P< 0.05), and there was no difference of the positive rate of anti-β2-GP I IgM in statistics between RSA patients and normal women (P>0.05). There was no difference of the positive rate of anti-β2-GP I in statistics between early and late, as well as between 2 times and more than 2 times abortions of RSA (P>0.05). Conclusion: The anti-β2-GP I antibody is related to RSA, and it may be regarded as a immunological assistant diagnostic index for RSA. (authors)