Published August 31, 1984 | Version v1
Journal article Metadata-only

Scintigraphy of normal mouse ovaries with monoclonal antibodies to ZP-2, the major zona pellucida protein

Creators

  • 1. National Inst. of Arthritis, Bethesda, MD

Description

The zona pellucida is an extracellular glycocalyx, made of three sulfated glycoproteins, that surrounds mammalian oocytes. Parenterally administered monoclonal antibodies specific for ZP-2, the most abundant zona protein, localize in the zona pellucida. When labeled with iodine-125, these monoclonal antibodies demonstrate a remarkably high target-to-nontarget tissue ratio and provide clear external radioimaging of ovarian tissue

Additional details

Publishing Information

Journal Title
Science (Washington, D.C.)
Journal Volume
225
Journal Issue
4665
Series
Science (Washington, D.C.).
Journal Page Range
938-941
ISSN
0036-8075

INIS

Country of Publication
United States
Country of Input or Organization
United States
INIS RN
16050366
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
DIAGNOSIS; IODINE 125; MICE; MONOCLONAL ANTIBODIES; OVARIES; SCINTISCANNING
Descriptors DEC
ANIMALS; ANTIBODIES; BETA DECAY RADIOISOTOPES; BODY; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; ELECTRON CAPTURE RADIOISOTOPES; FEMALE GENITALS; GONADS; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPES; MAMMALS; NUCLEI; ODD-EVEN NUCLEI; ORGANS; RADIOISOTOPE SCANNING; RADIOISOTOPES; RODENTS; VERTEBRATES