Published October 1986 | Version v1
Journal article Metadata-only

Regional cerebral uptake of Tc-99m-d,1-HM-PAO compared to other rCBF tracers

Creators

  • 1. H.S. Truman Veterans Hospital, Columbia, MO (USA). Research Service
  • 2. Missouri Univ., Columbia (USA). Dept. of Radiology
  • 3. Amersham International Ltd. (UK)

Description

Tc-99m forms a neutral-lipophilic chelate with d,1-4,8-diaza-3,6,6,9-tetramethylundecane-2,10-dione bis oxime (d,1-HM-PAO) that has excellent cerebral uptake and retention properties. Studies in humans and animals suggest that the regional cerebral uptake (rCU) of Tc-99m-d,1-HM-PAO is proportional to the regional cerebral blood flow (rCBF) and that there is minimal intracerebral redistribution. For this reason, this chelate is being used in conjunction with SPECT to evaluate patients with rCBF disorders. The rCU of Tc-99m-d,1-HM-PAO was compared to three other tracers commonly used to assess rCBF in laboratory animals: C-14-iodo-antipyrine, I-125-N-isopropyliodoamphetamine and Sn-113 microspheres. (author)

Additional details

Publishing Information

Journal Title
J. Labelled Compd. Radiopharm.
Journal Volume
23
Journal Issue
10-12
Series
J. Labelled Compd. Radiopharm.
Journal Page Range
1326-1328
ISSN
0362-4803
CODEN
JLCRD

Conference

Title
6. international symposium on radiopharmaceutical chemistry.
Dates
29 Jun - 3 Jul 1986.
Place
Boston, MA (USA).

INIS

Country of Publication
United Kingdom
Country of Input or Organization
United Kingdom
INIS RN
18082048
Subject category
S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
Resource subtype / Literary indicator
Conference
Descriptors DEI
AMPHETAMINES; ANTIPYRINE; BRAIN; CARBON 14 COMPOUNDS; COMPARATIVE EVALUATIONS; DIAZO COMPOUNDS; IODINE 125; MICROSPHERES; OXIMES; RABBITS; RADIOPHARMACEUTICALS; RATS; SINGLE PHOTON ECT; TECHNETIUM 99; TIN 113; TISSUE DISTRIBUTION
Descriptors DEC
AMINES; ANALEPTICS; ANALGESICS; ANIMALS; ANTIPYRETICS; AUTONOMIC NERVOUS SYSTEM AGENT; AZOLES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CARBON COMPOUNDS; CENTRAL NERVOUS SYSTEM; CENTRAL NERVOUS SYSTEM AGENTS; CENTRAL NERVOUS SYSTEM DEPRESS; COMPUTERIZED TOMOGRAPHY; DAYS LIVING RADIOISOTOPES; DISTRIBUTION; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; EMISSION COMPUTED TOMOGRAPHY; EVALUATION; EVEN-ODD NUCLEI; HETEROCYCLIC COMPOUNDS; HOURS LIVING RADIOISOTOPES; HYDROXY COMPOUNDS; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTO; IODINE ISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MAMMALS; MATERIALS; MINUTES LIVING RADIOISOTOPES; NERVOUS SYSTEM; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PYRAZOLES; PYRAZOLINES; RADIOACTIVE MATERIALS; RADIOISOTOPES; RODENTS; SYMPATHOMIMETICS; TECHNETIUM ISOTOPES; TIN ISOTOPES; TOMOGRAPHY; VERTEBRATES; YEARS LIVING RADIOISOTOPES