An electro-amalgamation approach to produce 175Yb suitable for radiopharmaceutical applications

175Yb is a prospective reactor produced radionuclide suitable for preparation of therapeutic radiopharmaceuticals. However, a major restraint in the use of 175Yb produced via the (n, γ) reaction, for therapeutic applications, is the presence of longer-lived 177Lu impurity which is co-produced along with 175Yb on irradiation of natural Yb2O3 target. A radiochemical separation procedure adopting electro-amalgamation approach for the removal of 177Lu impurity from 175Yb has been critically evaluated. The experimental parameters such as applied potential, electrolysis time and the pH of the electrolyte, affecting the electrochemical separation process, were studied and optimized. The developed radiochemical procedure was extensively tested for purification of up to 15 GBq of 175Yb. The purified 175Yb could be obtained in HCl medium with ∝ 95% yield. The 177Lu impurity could not be detected in the purified product and 175Yb was found suitable for the preparation of potential radiotherapeutic agents. (orig.)