Published February 2001
| Version v1
Journal article
Characterization of 3-[123I]iodo-L-α-methyl tyrosine ([123I]IMT) transport into human Ewing's sarcoma cells in vitro
Description
3-[123I]Iodo-L-α-methyl tyrosine ([123I]IMT) scintigraphy of extracranial malignant tumors has been described, but little is known about the transport systems involved in [123I]IMT uptake into extracranial tumor cells. Here, the precise kinetics of [123I]IMT transport into human Ewing's sarcoma cells (VH-64) was determined. The apparent Michaelis constant was of high affinity value (Km=41.7±3.9 μM) and maximum transport velocity amounted to Vmax=20.7±0.6 nmol·mg protein-1·10 min-1. Inhibition experiments revealed the predominance of [123I]IMT uptake via sodium-independent system L
Additional details
Identifiers
- PII
- S0969805100001864;
Publishing Information
- Journal Title
- Nuclear Medicine and Biology
- Journal Volume
- 28
- Journal Issue
- 2
- Journal Page Range
- p. 123-128
- ISSN
- 0969-8051
- CODEN
- NMBIEO
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- Brazil
- INIS RN
- 33036041
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- AFFINITY; IODINE 123; METHYL TYROSINE; RADIONUCLIDE KINETICS; RADIOPHARMACEUTICALS; SARCOMAS; SCINTISCANNING; UPTAKE
- Descriptors DEC
- AMINO ACIDS; AROMATICS; BETA DECAY RADIOISOTOPES; CARBOXYLIC ACIDS; COUNTING TECHNIQUES; DIAGNOSTIC TECHNIQUES; DISEASES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; HOURS LIVING RADIOISOTOPES; HYDROXY ACIDS; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPES; KINETICS; LABELLED COMPOUNDS; MATERIALS; NEOPLASMS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; RADIOACTIVE MATERIALS; RADIOISOTOPE SCANNING; RADIOISOTOPES
Optional Information
- Copyright
- Copyright (c) 2001 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.