Radioisotope incorporation via aryl- and alkenyl trialkyltin intermediates

Among the various demetallation methods available for the incorporation of radiohalogens, ipso electrophilic destannylation has proved to be one of the most versatile. Aryl- and alkenyl trialkylstannanes can be prepared by a number of methods and converted under mild conditions to their corresponding radiohalogenated analogs rapidly and in high yield at no carrier added levels. Examples of this method as utilized in the synthesis of labeled estrogens, progestins, dopamine antagonists and juvenile hormone analogs will be discussed