Published October 1986 | Version v1
Miscellaneous Metadata-only

Inhibition of human polimorfonuclear leucocyte migration by clofazimine: a new pro-oxidative anti-inflammatory agent

Creators

Description

Preliminary studies on the in vitro and in vivo effects of clofazimine on the function of polymorphonuclear leucocytes (PMNL) from normal individuals and patients with lepromatous leprosy showed that clofazimine caused a progressive dose-dependent inhibition of both random mortality of PMNL as well as migration of PMNL induced by the leucoattractant endotoxin-activated serum (EAS). The drug also increased chemiluminescence as well as hexose monophosphate shunt (HMS). These studies on clofazimine include the use of radiolabelling with 14C, 125I and 3H. Clofazimine-mediated inhibition of PMNL migration is dependent on intact membrane-associated oxidative metabolism. Clofazimine is therefore a pro-oxidative anti-inflammatory agent

Availability note (English)

Available from the Registrar, University of Pretoria, Pretoria, 0002, South Africa.

Additional details

Additional titles

Original title (Afrikaans)
Inhibisie van menslike polimorfonukleere leukosietmigrasie deur klofasimien: 'n nuwe pro-oksidatiewe meganisme van anti-inflammatoriese aktiwiteit

Publishing Information

Imprint Pagination
239 p.

INIS

Country of Publication
South Africa
Country of Input or Organization
South Africa
INIS RN
19054921
Subject category
S60: APPLIED LIFE SCIENCES;
Resource subtype / Literary indicator
Numerical Data, Thesis, Non-conventional Literature
Descriptors DEI
ALANINES; CHEMILUMINESCENCE; CHEMOTHERAPY; DRUGS; EXPERIMENTAL DATA; IN VITRO; IN VIVO; INFLAMMATION; INGESTION; INHIBITION; IODINATION; IODINE 125; KINETICS; LABELLED COMPOUNDS; LABELLING; LEPROSY; LEUKOCYTES; METABOLISM; MICROTUBULES; OXIDATION; PHAGOCYTOSIS; PROSTAGLANDINS; RADIOACTIVITY; RESPIRATION; SOLUTIONS
Descriptors DEC
AMINO ACIDS; BACTERIAL DISEASES; BETA DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY FLUIDS; CARBOXYLIC ACIDS; CELL CONSTITUENTS; CHEMICAL REACTIONS; DATA; DAYS LIVING RADIOISOTOPES; DISEASES; DISPERSIONS; ELECTRON CAPTURE RADIOISOTOPES; EMISSION; HALOGENATION; HOMOGENEOUS MIXTURES; INFECTIOUS DISEASES; INFORMATION; INTAKE; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTO; IODINE ISOTOPES; ISOTOPES; LUMINESCENCE; MATERIALS; MEDICINE; MIXTURES; NUCLEI; NUMERICAL DATA; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; PATHOLOGICAL CHANGES; PHOTON EMISSION; RADIOISOTOPES; THERAPY