A critical study of technetium 99m and xenon 133 lung scintigraphy in patients with cystic fibrosis
- 1. Hopital Regional, Lille (France)
- 2. Institut A. Calmette, Camiers (France)
Description
During investigations for cystic fibrosis, 41 children, most of whom were aged 0 to 7 years, were submitted to lung scintigraphy with technetium 99m first and xenon 133 subsequently. This procedure ensured accurate location of pulmonary lesions. The reliability of the radio-isotopic study was assessed through comparison to conventional clinical and radiological criteria, arterial blood gas determinations and pulmonary function tests. Perfusion scintigraphy with technetium 99m labelled macroaggregated albumin (n=90) was compared to functional parametrical xenon 133 study (n=25) (perfusion-ventilation). The degree of lung disease was evaluated during serial examinations in order to improve prognostic prediction. Technetium 99m scintigraphy proves a reliable and sensitive procedure which accurately reflects the patients' clinical status when it is performed in the absence of patent pulmonary superinfection. Xenon 133 scintigraphy, which is more difficult to perform and interpret, has the advantage of providing a topographic and quantitative evaluation of pulmonary blood flow and ventilatory efficiency
Abstract (French)
Dans le cadre du bilan de leur mucoviscidose, quarante et un enfants, ages de 0 a 7 ans, ont ete explores par scintigraphie pulmonaire au Technetium 99m, puis au Xenon 133. Cette etude a permis de preciser la topographie des lesions pulmonaires et de tester la fiabilite de l'examen radio-isotopique en le confrontant aux criteres habituels cliniques et radiologiques, a l'etude des gaz du sang ainsi qu'aux epreuves fonctionnelles respiratoires. Cette etude permet aussi de comparer la scintigraphie de perfusion aux macroagregats d'albumine marquee au Technetium 99m (n=90) avec l'etude fonctionnelle multiparametrique (perfusion-ventilation) au Xenon (n=25) et d'apprecier l'atteinte pulmonaire au cours d'examens successifs pour mieux formuler le pronostic. La scintigraphie au Technetium apparait comme un examen sur, sensible, bien representatif de l'etat clinique du malade lorsqu'elle est realisee en dehors de tout episode patent de surinfection pulmonaire. L'exploration au Xenon est plus delicate dans sa realisation et son interpretation; son avantage reside dans la possibilite d'une approche topographique et quantitative de la perfusion et de l'efficacite ventilatoireAdditional details
Additional titles
- Original title (French)
- Etude critique de la scintigraphie pulmonaire au technetium 99m et au xenon 133 chez les malades atteints de mucoviscidose
Publishing Information
- Journal Title
- Sem. Hop. Paris
- Journal Volume
- 59
- Journal Issue
- 27-28
- Series
- Sem. Hop. Paris.
- Journal Page Range
- 2043-2048
- ISSN
- 0037-1777
INIS
- Country of Publication
- France
- Country of Input or Organization
- France
- INIS RN
- 15002469
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- ALBUMINS; COMPARATIVE EVALUATIONS; FIBROSIS; LUNGS; RADIOPHARMACEUTICALS; SCINTISCANNING; TECHNETIUM 99; XENON 133
- Descriptors DEC
- BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DISEASES; DRUGS; EVEN-ODD NUCLEI; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTO; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MATERIALS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; PATHOLOGICAL CHANGES; PROTEINS; RADIOACTIVE MATERIALS; RADIOISOTOPE SCANNING; RADIOISOTOPES; RESPIRATORY SYSTEM; TECHNETIUM ISOTOPES; XENON ISOTOPES; YEARS LIVING RADIOISOTOPES