Tonographic effects of pilocarpine and pilocarpine-epinephrine in dogs

Topical pilocarpine (1.0, 2.0 and 4.0 per cent) and 2.0 per cent pilocarpine plus 1.0 per cent epinephrine markedly increased conventional aqueous humour outflow, as measured by non-invasive tomography, in both normal beagles and beagles with inherited glaucoma. Pilocarpine in normal eyes increased the coefficient or outflow from 0.33 mu-l/min/mmHg (pre-drug) to 0.55 mu-l/min/mmHg (1.0 per cent), 0.57 mu-l/min/mmHg (2.0 per cent), and 0.61 mu-l/min/mmHg (4.0 per cent). In beagles with inherited glaucoma, topical pilocarpine increased the coefficient of outflow from 0.15 mu-l/min/mmHg (pre-drug) to 0.24 mu-l/min/mmHg (1.0 per cent), 0.21 mu-l/min/mmHg (2.0 per cent) and 0.38 mu-l/min/mmHg (4.0 per cent). The 2.0 per cent pilocarpine plus 1.0 per cent epinephrine solution in normal eyes increased the coefficient of outflow from 0.27 mu-l/min/mmHg to 0.36 mu-l/min/mmHg. In the glaucomatous eyes the 2 per cent pilocarpine pus 1 per cent epinephrine combination, increased the coefficient outflow from 0.20 mu-l/min/mmHg to 0.30 mu-l/min/mmHg