Comparison of relative 18FDG uptake to metabolic rate (MRGlucose) in the myocardium in CAD, classified by 99mTc MIBI
Creators
- 1. RWTH, Klinikum Aachen (Germany). Klinik fuer Nuklearmedizin
- 2. RWTH, Klinikum Aachen (Germany). Medizinische Klinik 1
Description
In 55 non-diabetic patients with CAD, relative myocardial perfusion (99mTc MIBI SPECT at rest) and relative 18FDG uptake (PET after glucose load) were used to separate for various flow/metabolism constellations. In addition, regional glucose metabolic rate (rMRGlu in μmol/100 g/min; dynamic-graphic analysis from Gambhir/Patlak) was determined in 13 segments of the left ventricle each (i.e., in a total of 715 segments). rMRGlu revealed wide standard deviations (up to 51%). It decreased from normal (52.7±27.3 μmol/100 g/min), mismatch (45.3±17.3) and intermediate (35.2±12.4) to match ('non viable'; 26.7±13.3) significantly (p<0.01). In 26% of the perfusion maxima, MRGlu was <40 μmol/100 g/min. Out of these, only in five patients (of 28) with 3-vesell disease, it was even smaller (<30 μmol). In three out of the latter, glucose blood levels were below euglycemia. rMRGlu in CAD revealed an identical perfusion/metabolism pattern as relative 18FDG uptake. Thus, the higher efforts employed to compute rMRGlu do not yield diagnostic advantage. The segmental perfusion maximum, used for normalization of relative 18FDG uptake (100% MIBI uptake=100% FDG uptake) was reliable in euglycemic patients even with 3-vessel disease. (orig.)
Abstract (German)
Bei 55 Patienten mit KHK wurden die relative myokardiale Speicherung von 99mTc-MB (in Ruhe; SPECT) und von 18FDG (nach Glukoseladung, PET) vergleichend zu rMRGlu (in μmol/100 g/min) in je 13 Segmenten des linken Ventrikels (insgesamt 715 Segmente) bestimmt. Die rMRGlu zeigte Streubreiten von bis zu 51%. Sie nahm in der Reihenfolge normal (52,7±27,3 μmol/100 g/min), mismatch (p<0,01) ab. In 26% der Perfusionsmaxima war MRGlu <40 μmol/100 g/min, darunter nur bei fuenf Dreigefaesserkrankungen (von 28) <30 μmol. Die Serumglukosewerte zeigten bei drei dieser fuenf Patienten eine ungenuegende Antwort auf die orale Glukosebelastung. rMRGlu erbrachte bei KHK die gleichen Fluss/Stoffwechsel-Befundmuster wie die relative FDG-Speicherung. Der groessere Aufwand fuer die Berechnung von rMRGlu ergab keinen diagnostischen Vorteil. Das Perfusionsmaximum (100% MIBI) als Bezugwert fuer FDG (=100% FDG) war auch bei euglykaemisch eingestellten Patienten mit Dreigefaesserkrankungen verlaesslich. (orig.)Additional details
Additional titles
- Original title (German)
- Vergleich von relativer
Publishing Information
- Journal Title
- Nuklearmedizin
- Journal Volume
- 34
- Journal Issue
- 6
- Journal Page Range
- p. 223-228.
- ISSN
- 0029-5566
- CODEN
- NUKLDV
INIS
- Country of Publication
- Germany
- Country of Input or Organization
- Germany
- INIS RN
- 27041276
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- BIOLOGICAL LOCALIZATION; BLOOD FLOW; CARDIOVASCULAR DISEASES; FLUORINE 18; FLUORODEOXYGLUCOSE; GLUCOSE; METABOLISM; MYOCARDIUM; PATIENTS; POSITRON COMPUTED TOMOGRAPHY; RADIOPHARMACEUTICALS; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; TECHNETIUM COMPLEXES; TECHNETIUM 99; UPTAKE
- Descriptors DEC
- ALDEHYDES; ANIMALS; ANTIMETABOLITES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BODY; CARBOHYDRATES; CARDIOVASCULAR SYSTEM; COMPLEXES; COMPUTERIZED TOMOGRAPHY; DISEASES; DRUGS; EMISSION COMPUTED TOMOGRAPHY; FLUORINE ISOTOPES; HEART; HEXOSES; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; MAMMALS; MAN; MATERIALS; MONOSACCHARIDES; MUSCLES; NANOSEC LIVING RADIOISOTOPES; NUCLEI; ODD-EVEN NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; ORGANS; PRIMATES; RADIOACTIVE MATERIALS; RADIOISOTOPES; SACCHARIDES; TECHNETIUM ISOTOPES; TOMOGRAPHY; TRANSITION ELEMENT COMPLEXES; VERTEBRATES; YEARS LIVING RADIOISOTOPES