Increase of amidophosphoribosyltransferase activity and phosphoribosylpyrophosphate concentration as the basis for increased de novo purine biosynthesis in the regenerating rat liver

This study presents results of experiments that show that the labeling of hepatic purines with C 14-glycine increases in regenerating rat liver 12 hours after a 70% heptectomy and it reached the 2.4 folds higher peak 12 hours after the surgical operation in comparison to sham-operated control. These observations suggest that the rate of de novo biosynthesis increases in the regenerating rat lever to supply purine ribonucleotides tto the cells; this is mediated by the increased enzymatic activity of ATase and by the increased concentration of PRPP