Radioiodination of ammonio-closo-monocarborane, 1-H3N-1-CB11H11. Aspects of labelling chemistry in aqueous solution using Chloramine-T

The aim of this study was to investigate the use of electrophilic radioiodination in the labelling of closo-monocarborane(-1). Ammonio-closo-monocarborane (ACMC, 1-NH3-1-CB11H11) was labelled with 125I using Chloramine-T as an oxidant. Radio-TLC was used for analysis. Influence of substrate amount, oxidant concentration, and pH of the reaction media on the labelling yield was studied. A labelling yield of 80%-90% was obtained. The results of the study indicate feasibility to use derivatives of closo-monocarborane(-1) as a pendant group for indirect radioiodination of proteins, and for studying pharmacokinetics of boron-rich compounds for BNCT. (orig.)