Published 1981
| Version v1
Miscellaneous
Total lymphoid irradiation as an immunosuppressive regimen in monkeys and dogs
Creators
- 1. Gezondheidsorganisatie TNO, Rijswijk (Netherlands). Radiobiologisch Inst. TNO
Description
The authors have considered that total lymphoid irradiation (TLI) combined with bone marrow transplantation (BMT) might be an effective procedure for inducing organ graft tolerance. It is claimed that graft-versus-host disease (GVHD) is completely prevented in mice after TLI + BMT. They have attempted to verify these rodent observations in a preclinical animal model using an irradiation method and dosimetry previously described. Ten dogs (Beagles) and ten rhesus monkeys were included in the protocols and four treatment protocols were evaluated. (Auth.)
Additional details
Publishing Information
- Imprint Title
- REP Annual Report 1980
- Imprint Pagination
- 282 p.
- Journal Page Range
- p. 13-16.
- Report number
- INIS-mf--6804
INIS
- Country of Publication
- Netherlands
- Country of Input or Organization
- Netherlands
- INIS RN
- 13647668
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Resource subtype / Literary indicator
- Progress Report
- Descriptors DEI
- BONE MARROW; DOGS; EXTERNAL IRRADIATION; FRACTIONATED IRRADIATION; GRAFT-HOST REACTION; IMMUNOSUPPRESSION; LYMPHOCYTES; MONKEYS; TRANSPLANTS
- Descriptors DEC
- ANIMAL CELLS; ANIMALS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY; BODY FLUIDS; CONNECTIVE TISSUE CELLS; HEMATOPOIETIC SYSTEM; IRRADIATION; LEUKOCYTES; MAMMALS; ORGANS; PRIMATES; SOMATIC CELLS; TISSUES; VERTEBRATES