Published February 1998 | Version v1
Journal article Metadata-only

Relationship between transformation of human embryo lung cell and DNA strand break induced by γ-irradiation

Creators

  • 1. Institute of Radiation Medicine, Beijing (China)

Description

γ-irradiation effects on transformation and DNA strand break of human embryo lung cell were studied by means of cell and molecular biology. The cell transformation appeared at 20 th passage post 0.25∼5.0 Gy γ-irradiation. The transformation was relative to doses and post-time of irradiation. DNA strand break was detected by NTA (nick translation assay). The result indicated DNA strand break was arisen from γ ray with different doses. DNA strand break also was relative to radiation doses as cell transformation. Correlation between DNA strand break and cell transformation was analysed. The analysis indicated that effect of cell transformation enhanced with increase of DNA strand break. It was suggested that carcinogenesis by radiation is closely relative to DNA damage

Additional details

Publishing Information

Journal Title
Journal of Radiation Research and Radiation Processing
Journal Volume
16
Journal Issue
1
Journal Page Range
p. 50-53
ISSN
1000-3436

INIS

Country of Publication
China
Country of Input or Organization
China
INIS RN
29044103
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
CARCINOGENESIS; CELL CULTURES; COBALT 60; COLONY FORMATION; DNA; DOSE-RESPONSE RELATIONSHIPS; EMBRYONIC CELLS; LUNGS; RADIATION INJURIES; STRAND BREAKS; TRITIUM; X RADIATION
Descriptors DEC
ANIMAL CELLS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BODY; COBALT ISOTOPES; DISEASES; DNA DAMAGES; ELECTROMAGNETIC RADIATION; HYDROGEN ISOTOPES; INJURIES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; IONIZING RADIATIONS; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LIGHT NUCLEI; MINUTES LIVING RADIOISOTOPES; NUCLEI; NUCLEIC ACIDS; ODD-EVEN NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; ORGANS; PATHOGENESIS; RADIATION EFFECTS; RADIATIONS; RADIOISOTOPES; RESPIRATORY SYSTEM; YEARS LIVING RADIOISOTOPES