Published November 1992 | Version v1
Journal article Metadata-only

Synthesis of an iodine-125-labeled retinoid

Creators

  • 1. SRI International, Menlo Park, CA (United States)

Description

The carrier-free synthesis of 4-(5',6',7',8'-tetrahydro-4'-[125I]iodo-5',5',8',8'-tetramethyl-2'-a anthracenyl)benzoic acid (4'-[125I]TTAB) is described. Site specific radioiodination was accomplished by electrophilic destannylation of the tri(n-butyl)tin analog of the retinoid with Na125I and chloramine-T. 4'-[125I]TTAB (33 μCi, 1.65% radiochemical yield based on Na125I consumed) was purified by reversed-phase HPLC. (author)

Additional details

Publishing Information

Journal Title
Journal of Labelled Compounds and Radiopharmaceuticals
Journal Volume
31
Journal Issue
11
Journal Page Range
p. 865-869.
ISSN
0362-4803
CODEN
JLCRD4

INIS

Country of Publication
United Kingdom
Country of Input or Organization
United Kingdom
INIS RN
24035214
Subject category
S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
Descriptors DEI
AROMATICS; IODINE 125; LABELLED COMPOUNDS; LABELLING; MONOCARBOXYLIC ACIDS
Descriptors DEC
BETA DECAY RADIOISOTOPES; CARBOXYLIC ACIDS; DAYS LIVING RADIOISOTOPES; ELECTRON CAPTURE RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTO; IODINE ISOTOPES; ISOTOPES; NUCLEI; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; RADIOISOTOPES

Optional Information

Contract/Grant/Project number
Contract NCI 263-MD-122477; Grant USPHS NCI P01 CA51993