Published December 1986
| Version v1
Journal article
Intestinal absorption and fecal excretion of 5,6 alpha-epoxy-5 alpha-cholesta-3 beta-ol by the male Wistar rat
- 1. INSERM U. 58, Montpellier, France
Description
The intestinal absorption of 5,6 alpha-epoxy-5 alpha-cholesta-3 beta-ol, an oxysterol formed by cholesterol autoxidation, has been evaluated in the male Wistar rat. Measurement of the 14C/3H ratio in the serum (by the method of Zilversmit and Hugues) and in the feces showed that a large proportion of the epoxide was absorbed. Epoxide clearance from the blood was very rapid, but its excretion in the stool continued for several days, corresponding to the fraction of the epoxide stored in the animal
Additional details
Publishing Information
- Journal Title
- Lipids
- Journal Issue
- no.12
- Series
- Lipids.
- ISSN
- 0024-4201
- CODEN
- LPDSA
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 18073181
- Subject category
- S60: APPLIED LIFE SCIENCES;
- Descriptors DEI
- BIOCHEMICAL REACTION KINETICS; BLOOD-PLASMA CLEARANCE; CARBON 14 COMPOUNDS; CHOLESTEROL; EXCRETION; FECES; INTESTINAL ABSORPTION; ISOTOPE RATIO; METABOLISM; RATS; TRITIUM COMPOUNDS
- Descriptors DEC
- ANIMALS; BIOLOGICAL MATERIALS; BIOLOGICAL WASTES; CARBON COMPOUNDS; CLEARANCE; HYDROGEN COMPOUNDS; HYDROXY COMPOUNDS; KINETICS; MAMMALS; MATERIALS; ORGANIC COMPOUNDS; REACTION KINETICS; RODENTS; STEROIDS; STEROLS; UPTAKE; VERTEBRATES; WASTES