Published March 1976 | Version v1
Journal article Metadata-only

Stimulation and inhibition of erythropoiesis in donors and hematopoietic effect in irradiated recipient

Creators

  • 1. Belgrade Univ. (Yugoslavia). Inst. of Histology
  • 2. Institut za Nuklearne Nauke Boris Kidric, Vinca (Yugoslavia)

Description

Regeneration dynamics in bone marrow and spleen was studied in rats after irradiation of 800 R and transfusion of bone marrow cells from donors treated in different ways. Priority of the microenvironment of the recipient or of the information obtained in cell donors with respect to further hematopoietic cell differentiation was studied in irradiated recipients. Rats irradiated with 800 R were used as recipients in the experiments. The donors of marrow cells were the rats with stimulated or inhibited erythropoiesis. Stimulation of erythropoiesis was induced by bleeding and experimental polycythemia was provoked by packed erythrocytes. According to our results, it can be concluded that the processes of postirradiation hematopoiesis after transplantation of the bone marrow cells depend on the number and proliferative state of both donors and recipient stem cells, and microenvironment, not excluding the information introduced with the donor cell transplant. (orig.)

Abstract (German)

Regenerationsvorgaenge in Knochenmark und Milz wurden nach Bestrahlung mit 800 R und Uebertragung von Knochenmarkzellen, die von unterschiedlich behandelten Spendern stammten, an Ratten untersucht. Am bestrahlten Empfaenger wurde im Hinblick auf die weitere haematopoetische Zelldifferenzierung geprueft, ob dem Mikromilieu im Empfaenger groessere Bedeutung zukommt oder der in den Spenderzellen enthaltenen Information. Mit 800 R bestrahlte Ratten wurden in den Experimenten als Empfaenger verwendet. Spender der Markzellen waren Ratten mit stimulierter oder gehemmter Erythropoese. Die Stimulation der Erytropoese wurde durch Blutverlust bewirkt, die experimentelle Polyzythaemie durch Erythrozytenkonzentrat hervorgerufen. Aus unseren Ergebnissen ist zu schliessen, dass die Vorgaenge bei der Haematopoese nach Bestrahlung und Uebertragung von Knochenmarkzellen von der Anzahl und dem Wachstumverhalten (Proliferationsstadium) der Stammzellen des Spenders wie auch des Empfaengers abhaengen, aber auch vom Mikromilieu und schliesslich von der mit dem Zelltransplantat uebertragenen Information. (orig.)

Additional details

Publishing Information

Journal Title
Strahlentherapie
Journal Volume
151
Journal Issue
3
Series
Strahlentherapie.
Journal Page Range
247-252

Conference

Title
4. annual conference of the International Society of Experimental Hematology.
Dates
21 Sep 1975.
Place
Trogir, Yugoslavia.

INIS

Country of Publication
Germany
Country of Input or Organization
Germany
INIS RN
7260118
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Resource subtype / Literary indicator
Conference
Descriptors DEI
BIOLOGICAL REGENERATION; BONE MARROW; BONE MARROW CELLS; CELL PROLIFERATION; ERYTHROPOIESIS; INHIBITION; IONIZING RADIATIONS; RADIATION INJURIES; RATS; SPLEEN; STEM CELLS; STIMULATION; TRANSPLANTS; WHOLE-BODY IRRADIATION
Descriptors DEC
ANIMAL CELLS; ANIMALS; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BIOLOGICAL RECOVERY; BLOOD FORMATION; BODY; CONNECTIVE TISSUE CELLS; DISEASES; EXTERNAL IRRADIATION; HEMATOPOIETIC SYSTEM; INJURIES; IRRADIATION; MAMMALS; ORGANS; RADIATION EFFECTS; RADIATIONS; RODENTS; SOMATIC CELLS; TISSUES; VERTEBRATES

Optional Information

Notes
2 figs.; 4 tabs.; 17 refs.
Secondary number(s)
AED-Conf--75-464-000.