Mesenchymal stem cells reduce the irradiation induced lung injury
- 1. Department of Radiation Oncology, Affiliated Hospital to Academy of Military Medical Science, Beijing (China)
Description
Objective: To evaluate the role of mesenchymal stem cells (MSCs) derived from mouse bone and embryo dorsal aorta (DA) area in the treatment of irradiation induced lung injury of mouse model. Methods: The mice were divided into four groups as normal control group, irradiation group,bone MSCs treatment group and DA MSCs treatment group. Immunohistochemical Analysis of lung tissue was observed after 9 months of treatment. Results: Fibrosis and alveolar infiltration were scored in each group. The score for fibrosis and alveolar is 0. 17 in normal control group, 2 in irradiation group, 1 in bone MSCs treat group and 1.38 in DA MSCs treat group. Conclusion: The extent of irradiation Induced Lung Injury could be reduced thorough the treatment of MSCs derived from mouse bone and embryos dorsal aorta ( DA ) area. (authors)
Additional details
Publishing Information
- Journal Title
- Chinese Journal of Radiological Medicine and Protection
- Journal Volume
- 30
- Journal Issue
- 6
- Journal Page Range
- p. 670-673
- ISSN
- 0254-5098
INIS
- Country of Publication
- China
- Country of Input or Organization
- China
- INIS RN
- 46111155
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- ANIMAL TISSUES; AORTA; EMBRYOS; IRRADIATION; LUNGS; MICE; PATHOLOGY; RADIATION INJURIES; SKELETON; STEM CELLS; THERAPY
- Descriptors DEC
- ANIMAL CELLS; ANIMALS; ARTERIES; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BLOOD VESSELS; BODY; CARDIOVASCULAR SYSTEM; DISEASES; INJURIES; MAMMALS; MEDICINE; ORGANS; RADIATION EFFECTS; RESPIRATORY SYSTEM; RODENTS; SOMATIC CELLS; VERTEBRATES
Optional Information
- Notes
- 3 figs., 19 refs.