Published 1982
| Version v1
Report
Coupling of dextrans conjugated with boron to γ globulin: a model for NCT
Description
To achieve the selective localization of boron in or on cancer cells or other target cells, the authors have elected to use water-soluble dextrans as intermediate carriers. This permits each MCA molecule to target many atoms of boron-10 to the specified antigenic receptors while only 5 to 10 of the amino acid residues of the protein are conjugated by dextrans carrying boron-10. As a result, there should be little of the loss of receptor specificity or affinity
Additional details
Publishing Information
- Imprint Title
- Proceedings of the first international symposium on neutron capture therapy
- Journal Page Range
- p. 237-244.
- Report number
- BNL--51730
Conference
- Title
- Symposium on neutron capture therapy.
- Dates
- 12-14 Oct 1983.
- Place
- Boston, MA (USA).
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 16063157
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY; S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Resource subtype / Literary indicator
- Conference
- Descriptors DEI
- BIOLOGICAL LOCALIZATION; BORON 10; CHEMICAL REACTIONS; DEXTRAN; GLOBULINS-GAMMA; ION EXCHANGE CHROMATOGRAPHY; MONOCLONAL ANTIBODIES; NEUTRON CAPTURE THERAPY; RECEPTORS; TUMOR CELLS
- Descriptors DEC
- ANIMAL CELLS; ANTIBODIES; BLOOD SUBSTITUTES; BORON ISOTOPES; CARBOHYDRATES; CHROMATOGRAPHY; GLOBULINS; ISOTOPES; LIGHT NUCLEI; MEDICINE; NEUTRON THERAPY; NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; POLYSACCHARIDES; PROTEINS; RADIOTHERAPY; SACCHARIDES; SEPARATION PROCESSES; STABLE ISOTOPES; THERAPY