Published March 1993 | Version v1
Journal article Metadata-only

X-ray-induced DNA double-strand breaks as lethal lesions in diploid human fibroblasts compared to Chinese hamster ovary cells

Creators

  • 1. Radiologische Universitaetsklinik, Bonn (Germany). Experimentelle Radiologie und Strahlenbiologie

Description

Calibration of the non-denaturing (pH9.6) filter elution technique by 125I decays has been used to examine the relationship between X-ray induced DNA double-strand breaks (dsb) and cellular survival of CHO cells and human fibroblasts. DNA dsb induction varies markedly between the two cell lines, reflecting the different survival levels. The relationships between lethal lesions (-1n S) and DNA dsb are also significantly different for CHO cells and human fibroblasts, suggesting either different probabilities of dsb conversion into lethal lesions or different repair capacities. (Author)

Additional details

Publishing Information

Journal Title
International Journal of Radiation Biology
Journal Volume
63
Journal Issue
3
Journal Page Range
p. 305-311.
ISSN
0955-3002
CODEN
IJRBE7

INIS

Country of Publication
United Kingdom
Country of Input or Organization
United Kingdom
INIS RN
24053331
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
CALIBRATION; CELL KILLING; CHO CELLS; COMPARATIVE EVALUATIONS; DNA; ELUTRIATION; FIBROBLASTS; IODINE 125; LETHAL IRRADIATION; STRAND BREAKS; SURVIVAL CURVES; X RADIATION
Descriptors DEC
ANIMAL CELLS; BETA DECAY RADIOISOTOPES; CONNECTIVE TISSUE CELLS; DAYS LIVING RADIOISOTOPES; ELECTROMAGNETIC RADIATION; ELECTRON CAPTURE RADIOISOTOPES; EVALUATION; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTO; IODINE ISOTOPES; IONIZING RADIATIONS; IRRADIATION; ISOTOPES; NUCLEI; NUCLEIC ACIDS; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; RADIATIONS; RADIOISOTOPES; SEPARATION PROCESSES; SOMATIC CELLS