Production, quality control, biodistribution and imaging studies of 177Lu-PSMA-617 in breast adenocarcinoma model
Creators
- 1. Nuclear Science and Technology Research Institute, Tehran (Iran, Islamic Republic of). Materials and Nuclear Fuel Research School
- 2. International Atomic Energy Agency (IAEA), Vienna (Austria). Radioisotope Products and Radiation Technology Section
- 3. Nuclear Science and Technology Research Institute, Tehran (Iran, Islamic Republic of). Radiation Application Research School
Description
177Lu-PSMA-617 therapeutic agent was prepared successfully under optimized condition of pH=4.5, molar ratio of metal to ligand 1:10, temperature of 95 C and 40 min reaction time. 177LuCl3 was obtained with specific activity of 70-80 GBq/mg by the thermal neutron irradiation (5 x 1013 n cm-2 s-1) of the enriched Lu2O3 (52% 176Lu) samples. The radionuclidic purity of 177LuCl3 (>99%) was checked by a HPGe detector. The radiochemical purities of 177LuCl3 solution and 177Lu-PSMA-617 compound (>98%) were checked by ITLC and HPLC techniques and stability studies were assayed in the presence of human serum. Biodistribution and imaging assessments in the breast adenocarcinoma-bearing mice showed a major accumulation of activity in the tumor and kidneys tissues, as the expression site of PSMA molecule and the main route of excretion, respectively.
Additional details
Publishing Information
- Journal Title
- Radiochimica Acta
- Journal Volume
- 106
- Journal Issue
- 6
- Journal Page Range
- p. 507-513
- ISSN
- 0033-8230
- CODEN
- RAACAP
INIS
- Country of Publication
- Germany
- Country of Input or Organization
- Germany
- INIS RN
- 49084618
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- ANTIGENS; BIOLOGICAL ACCUMULATION; CARCINOMAS; DIAGNOSTIC USES; LUTETIUM 177; MAMMARY GLANDS; MICE; NUCLEAR MEDICINE; PEPTIDES; POSITRON COMPUTED TOMOGRAPHY; PRODUCTION; QUALITY ASSURANCE; RADIOCHEMISTRY; RADIOPHARMACEUTICALS; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; UPTAKE
- Descriptors DEC
- ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CHEMISTRY; COMPUTERIZED TOMOGRAPHY; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DISEASES; DRUGS; EMISSION COMPUTED TOMOGRAPHY; GLANDS; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; LUTETIUM ISOTOPES; MAMMALS; MANAGEMENT; MATERIALS; MEDICINE; NEOPLASMS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; PROTEINS; QUALITY MANAGEMENT; RADIOACTIVE MATERIALS; RADIOISOTOPES; RARE EARTH NUCLEI; RODENTS; TOMOGRAPHY; USES; VERTEBRATES