Published January 1979
| Version v1
Journal article
Sensitive radioimmunoassay for somatostatin using N-[125I]-tyr-somatostatin as labelled antigen
Creators
- 1. CHUL, Quebec (Canada). Lab. of Molecular Endocrinology and Service of Gastro-Enterology
Description
A sensitive radioimmunoassay for somatostatin using N-(125I]-Tyr-somatostatin is described and compared with using [125I]-Tyr1-somatostatin. The minimum detectable amount of somatostatin using N-[125I]-Tyr-somatostatin as tracer was 0.1 to 0.5 pg, which is approximately 10-fold lower detection limit of the RIA using [125I]-Tyr1-somatostatin. Moreover, it was found that the shelf-life of N-[125I]-Tyr-somatostatin was prolonged in comparison with labelled Tyr1-somatostatin. Human pancreatic and gastric extracts displayed immunological similarity to synthetic somatostatin tetradecapeptide. (author)
Additional details
Publishing Information
- Journal Title
- Clin. Endocrinol.
- Journal Volume
- 10
- Journal Issue
- 1
- Series
- Clin. Endocrinol.
- Journal Page Range
- 47-54
- ISSN
- 0300-0664
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- United Kingdom
- INIS RN
- 10473161
- Subject category
- S60: APPLIED LIFE SCIENCES;
- Resource subtype / Literary indicator
- Numerical Data
- Descriptors DEI
- ANTIGENS; DECOMPOSITION; EXPERIMENTAL DATA; GRAPHS; IODINE 125; LABELLED COMPOUNDS; MOLECULAR STRUCTURE; PEPTIDE HORMONES; RADIOIMMUNOASSAY; SENSITIVITY; STORAGE; TABLES; TYROSINE
- Descriptors DEC
- AMINO ACIDS; AROMATICS; BETA DECAY RADIOISOTOPES; CARBOXYLIC ACIDS; CHEMICAL REACTIONS; DATA; DATA FORMS; DAYS LIVING RADIOISOTOPES; ELECTRON CAPTURE RADIOISOTOPES; HORMONES; HYDROXY ACIDS; INFORMATION; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; NUCLEI; NUMERICAL DATA; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; RADIOISOTOPES; TRACER TECHNIQUES