Activation of platelet aggregation and arachidonate metabolism in early stage of acute radiation injury
Creators
- 1. Shanghai Medical Univ. (China). Shanghai Inst. of Radiation Medicine
Description
The paper describes the changes of platelet aggregation and arachidonate metabolism in platelets and endothelial cells after 8.0-8.5 Gy γ-ray whole-body irradiation in rats. It was found that with 8.0 Gy exposure platelet aggregation rate and speed, and plasma TxB2 level were increased at 4h and on the 1st day post irradiation, and that 6-keto-PGF1α level was enhanced at 4h, then reduced to the control level on the 1st day post irradiation. The result of biological assay showed the ability for rat platelets to convert exogenous arachidonate into TxA2 was significantly raised at 4h and on the 1st day after 8.5 Gy γ-ray irradiation. It is suggested that the activation of platelet arachidonate metabolism may be one of the important causes of acute radiation injury is suggested that the activation of platelet arachidonate metabolism may be one of the important causes of acute radiation injury
Additional details
Publishing Information
- Journal Title
- Chinese Journal of Radiological Medicine and Protection
- Journal Volume
- 10
- Journal Issue
- 5
- Series
- Chin. J. Radiol. Med. Prot.
- Journal Page Range
- 297-300
- ISSN
- 0254-5098
- CODEN
- ZFYZD
INIS
- Country of Publication
- China
- Country of Input or Organization
- China
- INIS RN
- 22083984
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- AGGLOMERATION; ARACHIDONIC ACID; BIOLOGICAL RADIATION EFFECTS; BLOOD PLATELETS; GAMMA RADIATION; METABOLISM; RATS; WHOLE-BODY IRRADIATION
- Descriptors DEC
- ANIMALS; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY FLUIDS; CARBOXYLIC ACIDS; ELECTROMAGNETIC RADIATION; EXTERNAL IRRADIATION; IONIZING RADIATIONS; IRRADIATION; MAMMALS; MATERIALS; MONOCARBOXYLIC ACIDS; ORGANIC ACIDS; ORGANIC COMPOUNDS; RADIATION EFFECTS; RADIATIONS; RODENTS; VERTEBRATES