Renal handling of technetium-99m DMSA: Evidence for glomerular filtration and peritubular uptake
Creators
- 1. University Hospital, Groningen (Netherlands)
Description
The finding of an enhanced excretion of [99mTc]dimercaptosuccinic acid (DMSA) in patients with tubular reabsorption disorders prompted us to investigate the role of filtration in the renal handling of [99mTc]DMSA. Our studies in human serum indicated that binding to serum proteins was approximately 90%. Chromatography of human urine and studies in rats showed that the complex was excreted unaltered into the urine. Renal extraction of [99mTc]DMSA in a human volunteer was 5.8%. Continuous infusion of [99mTc]DMSA in 13 individuals with normal renal function gave the following results (mean +/- s.d.): plasma clearance of [99mTc]DMSA 34 +/- 4 ml/min, urinary clearance of [99mTc]DMSA 12 +/- 3 ml/min. The calculated filtered load of [99mTc]DMSA closely resembled the urinary clearance, whereas the plasma clearance was about three times faster. This indicates that peritubular uptake accounts for approximately 65% and filtration for approximately 35% of the renal handling of [99mTc]DMSA
Additional details
Publishing Information
- Journal Title
- Journal of Nuclear Medicine
- Journal Volume
- 30
- Journal Issue
- 7
- Series
- J. Nucl. Med.
- Journal Page Range
- 1219-1223
- ISSN
- 0161-5505
- CODEN
- JNMEA
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 21007257
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- BLOOD-PLASMA CLEARANCE; DIAGNOSIS; ISOMERIC NUCLEI; KIDNEYS; METABOLISM; PATIENTS; PROTEINS; RADIOPHARMACEUTICALS; RATS; RENAL CLEARANCE; SUCCINIC ACID; TECHNETIUM 99; THIOLS; UPTAKE; UROGENITAL SYSTEM DISEASES
- Descriptors DEC
- ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CARBOXYLIC ACIDS; CLEARANCE; DICARBOXYLIC ACIDS; DISEASES; DRUGS; EXCRETION; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTO; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MAMMALS; MATERIALS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC SULFUR COMPOUNDS; ORGANS; RADIOACTIVE MATERIALS; RADIOISOTOPES; RODENTS; TECHNETIUM ISOTOPES; VERTEBRATES; YEARS LIVING RADIOISOTOPES