Published May 1, 2021
| Version v1
Journal article
Analysis of Chromatin Opening in Heterochromatic Non-Small Cell Lung Cancer Tumor-Initiating Cells in Relation to DNA-Damaging Antitumor Treatment
Creators
- 1. Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm (Sweden)
- 2. Department of Oncology-Pathology, Karolinska Institutet, Stockholm (Sweden)
- 3. Biomedical Physics Division, Institute of Experimental Physics, Faculty of Physics, University of Warsaw (Poland)
- 4. Department of Radiobiology and Immunology, Institute of Biology, Jan Kochanowski University, Kielce (Poland)
Description
We previously reported that sphere-forming non-small cell lung cancer (NSCLC) tumor-initiating cells (TICs) have an altered activation of DNA damage response- and repair proteins and are refractory to DNA-damaging treatments. We analyzed whether chromatin organization plays a role in the observed refractoriness.
Availability note (English)
Available from http://dx.doi.org/10.1016/j.ijrobp.2017.09.033Additional details
Identifiers
- DOI
- 10.1016/j.ijrobp.2017.09.033;
- PII
- S0360301617339330;
Publishing Information
- Journal Title
- International Journal of Radiation Oncology, Biology and Physics
- Journal Volume
- 100
- Journal Issue
- 1
- Journal Page Range
- p. 174-187
- ISSN
- 0360-3016
- CODEN
- IOBPD3
INIS
- Country of Publication
- United States
- Country of Input or Organization
- International Atomic Energy Agency (IAEA)
- INIS RN
- 54107077
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- CHROMATIN; DNA; DNA DAMAGES; LUNGS; NEOPLASMS; PROTEINS; REPAIR; SPHERES
- Descriptors DEC
- BODY; DISEASES; NUCLEIC ACIDS; ORGANIC COMPOUNDS; ORGANS; RESPIRATORY SYSTEM
Optional Information
- Copyright
- Copyright (c) 2017 Elsevier Inc. All rights reserved.