Synthesis of some new sulfonamide derivatives of expected anticancer and radiosensitizing activities

In a search for new cytotoxic agents with improved activity and selectivity, certain new sulfonamide derivatives were synthesized. All the newly synthesized compounds were subjected to in vitro cytotoxic screening against human hepatocellular liver carcinoma cell line (HEPG2). The most potent compounds, as concluded from this screening, were selected to be evaluated again for their in vitro cytotoxic activity in combination with γ-radiation. The new compounds were docked inside the active site of histone de acetylase enzyme in an attempt to predict their mechanism of action