Aging, regional cerebral blood flow, and neuropsychological functioning
Creators
- 1. Creighton Univ. School of Medicine, Omaha, NE
Description
Previous studies found changes in regional cerebral blood flow (rCBF) patterns related to both age and various cognitive tasks. However, no study has yet demonstrated a relationship between rCBF and performance on the Luria-Nebraska Neuropsychological Battery (LNNB) in an elderly group. Seventy-nine elderly volunteers (56-88 years old), both healthy and demented, underwent the 133xenon inhalation rCBF procedure and were given the LNNB. The decrements in the gray-matter blood flow paralleled decrements in performance on the LNNB. Using partial correlations, a significant proportion of shared variance was observed between gray-matter blood flow and the LNNB scales. However, there was much less of a relationship between white-matter blood flow and performance on the LNNB. This study suggests that even within a restricted age sample rCBF is related in a global way to neuropsychological functioning
Additional details
Publishing Information
- Journal Title
- J. Am. Geriatr. Soc.
- Journal Volume
- 32
- Journal Issue
- 10
- Series
- J. Am. Geriatr. Soc.
- Journal Page Range
- 712-718
- ISSN
- 0002-8614
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 16067647
- Subject category
- S60: APPLIED LIFE SCIENCES;
- Descriptors DEI
- AGE DEPENDENCE; BLOOD FLOW; CEREBRUM; DYNAMIC FUNCTION STUDIES; LIFE SPAN; NERVOUS SYSTEM; TRACER TECHNIQUES; XENON 133
- Descriptors DEC
- BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; BRAIN; CENTRAL NERVOUS SYSTEM; DAYS LIVING RADIOISOTOPES; EVEN-ODD NUCLEI; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTO; ISOMERIC TRANSITION ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; NUCLEI; ORGANS; RADIOISOTOPES; XENON ISOTOPES