Published 1978
| Version v1
Journal article
Effect of dexamethasone on protein extravasation in the brain in acute hypertension induced by amphetamine
Description
Amphetamine produces protein leakage in the brain when given to rats under nitrous oxide anesthesia. The blood-brain barrier dysfunction is caused by the combined effect of blood pressure increase and vasodilatation. In the present experiments pretreatment with dexamethasone, 2 mg. kg-1, diminished the amphetamine-induced extravasation of Evans blue albumin and 125IHSA in the rats' brain. Possible explanations to the effect of dexamethasone on cerebrovascular permeability are discussed. (author)
Additional details
Publishing Information
- Journal Title
- Acta Neurol. Scand.
- Journal Volume
- 57
- Series
- Acta Neurol. Scand.
- Journal Page Range
- 180-185
INIS
- Country of Publication
- Denmark
- Country of Input or Organization
- Denmark
- INIS RN
- 9395131
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- ALBUMINS; BENZEDRINE; BRAIN; DEXAMETHASONE; HYPERTENSION; PROTEINS; RATS
- Descriptors DEC
- ADRENAL HORMONES; AMINES; ANIMALS; BODY; CARDIOVASCULAR DISEASES; CENTRAL NERVOUS SYSTEM; CORTICOSTEROIDS; DISEASES; DRUGS; GLUCOCORTICOIDS; HORMONES; HYDROXY COMPOUNDS; KETONES; MAMMALS; NERVOUS SYSTEM; ORGANIC COMPOUNDS; ORGANS; PREGNANES; RODENTS; STEROID HORMONES; STEROIDS; SYMPATHOMIMETICS; SYMPTOMS; VASCULAR DISEASES; VERTEBRATES