The effect of early application of tirofiban on CRP levels in patients with acute myocardial infarction after emergency percutaneous coronary intervention

Objective: To evaluate the effect of Tirofiban on CRP levels in patients with acute myocardial infarction (AMI) after primary emergency percutaneous coronary intervention (PCI). Methods: Eighty-four AMI patients admitted on emergency were randomly divided into two groups: (1) early-treated group (n = 45), immediately receiving Tirofiban intravenously on admission and (2) late-treated group (n = 39), receiving Tirofiban intravenously after coronary angiography was performed. TIMI grading before and after PCI in both groups were compared, CRP levels before and three days after PCI were estimated. The major adverse cardiovascular events (MACEs) occurred during hospitalization and following-up period of three months were recorded. Results: Before PCI, TIMI grade 3 forward flow rate in early-treated group was significantly higher than that in late-treated group, while no significant difference existed between two groups after PCI. Three days after PCI, CRP level in early-treated group was markedly lower than that in late-treated group. During hospitalization, the occurrence of MACEs in early-treated group was lower than that in latetreated group, while no marked difference was found between two groups during the following-up period of three months. Conclusion: In treating AMI patients with primary PCI, Tirofiban should be used as early as possible, which is safe and effective for PCI and can also significantly improve forward blood flow in target vessels, decrease the CRP level and reduce the occurrence of MACEs during hospitalization. (authors)