Published 2019 | Version v1
Journal article Metadata-only

New evolutions in biological modeling. For improved clinical effectiveness

Creators

  • 1. National Institutes for Quantum and Radiological Science and Technology, National Institute of Radiological Sciences, Department of Accelerator and Medical Physics, Chiba (Japan)

Description

Recently, advanced treatment techniques such as respiratory gating, scanning irradiation, and intensity-modulated particle therapy have been developed and utilized worldwide. To make the best use of these techniques and increase the clinical effectiveness of charged-particle therapy, it is important to investigate the effects of repair and oxygen enhancement ratio (OER) on biological effectiveness of the therapy. If the effects are non-negligible, the effects should be considered in clinical RBE system. In this chapter, recent efforts to investigate these effects are briefly overviewed. (author)

Availability note (English)

Available from DOI: https://doi.org/10.3769/radioisotopes.68.377

Abstract (Japanese)

近年,呼吸同期照射法,スキャニング照射法や強度変調粒子線治療などの高度な治療技術が開発され,高精度な粒子線治療が可能になってきている。これらの技術を活かしながらより高い治療効果を実現するためには,現在の臨床効果モデルでは反映してこなかった,修復や酸素効果などの放射線感受性を左右する因子をも適切に線量設計に反映すべきであろう。本稿では,それらの取り組みについて紹介する。(著者)

Additional details

Additional titles

Original title (Japanese)
生物効果モデルに関わる新たな展開.より高い治療効果の実現に向けた取り組み

Identifiers

DOI
10.3769/radioisotopes.68.377;

Publishing Information

Journal Title
Radioisotopes (Online)
Journal Volume
68
Journal Issue
6
Journal Page Range
p. 377-382
ISSN
1884-4111

INIS

Country of Publication
Japan
Country of Input or Organization
Japan
INIS RN
52108381
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
CELL NUCLEI; CLINICAL TRIALS; EXTERNAL BEAM RADIATION THERAPY; IONIZING RADIATIONS; LET; MICRODOSIMETRY; NEOPLASMS; PARTICLE BEAMS; POISSON RATIO; PROSTATE; RADIATION DOSE DISTRIBUTIONS; RBE; SURVIVAL CURVES; THERAPEUTIC DOSES
Descriptors DEC
BEAMS; BODY; CELL CONSTITUENTS; DIMENSIONLESS NUMBERS; DISEASES; DOSES; DOSIMETRY; ENERGY TRANSFER; GLANDS; MALE GENITALS; MECHANICAL PROPERTIES; MEDICINE; NUCLEAR MEDICINE; ORGANS; RADIATIONS; RADIOLOGY; RADIOTHERAPY; TESTING; THERAPY

Optional Information

Notes
8 refs., 5 figs.