Published November 2019 | Version v1
Journal article Metadata-only

BIBR1532, a Selective Telomerase Inhibitor, Enhances Radiosensitivity of Non-Small Cell Lung Cancer Through Increasing Telomere Dysfunction and ATM/CHK1 Inhibition

Creators

  • 1. Department of Radiation Oncology and Cyberknife Center, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin's Clinical Research Center for Cancer, Tianjin (China)
  • 2. Department of Radiation Oncology, First Affiliated Hospital of USTC(University of Science and Technology of China), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui (China)
  • 3. Second Affiliated Hospital of Harbin Medical University, Harbin, 150081 (China)

Description

Telomerase is reactivated in non-small cell lung cancer (NSCLC), and it increases cell resistance to irradiation through protecting damaged telomeres and enhancing DNA damage repair. We investigated the radiosensitizing effect of BIBR1532, a highly selective telomerase inhibitor, and its corresponding mechanism in NSCLC.

Additional details

Identifiers

DOI
10.1016/j.ijrobp.2019.08.009;
PII
S0360301619336429;

Publishing Information

Journal Title
International Journal of Radiation Oncology, Biology and Physics
Journal Volume
105
Journal Issue
4
Journal Page Range
p. 861-874
ISSN
0360-3016
CODEN
IOBPD3

INIS

Country of Publication
United States
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
55057307
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
DNA DAMAGES; DNA REPAIR; INHIBITION; IRRADIATION; LUNGS; NEOPLASMS; RADIOSENSITIVITY; TELOMERES
Descriptors DEC
BIOLOGICAL RECOVERY; BIOLOGICAL REPAIR; BODY; DISEASES; ORGANS; REPAIR; RESPIRATORY SYSTEM; SENSITIVITY

Optional Information

Copyright
Copyright (c) 2019 The Authors. Published by Elsevier Inc.