Research progress in radiotherapy for brain metastases of non-small cell lung cancer

Since the first application of whole brain radiation therapy (WBRT) to brain metastases in 1950 s, it has been regarded as a standard treatment for brain metastases of non-small cell lung cancer (NSCLC). Recently, more accurate radiotherapy technique and more effective systemic therapy have been developed. Especially, the molecular targeted drugs are upgraded rapidly with stronger targeting capability and better permeability of the central nervous system. With the prolonged survival of patients, long-term damage to the nervous system induced by WBRT causes widespread concerns. This article will review the related controversies and research progress in the application of WBRT to NSCLC with brain metastases in modern integrated therapy. (authors)