Published July 17, 1985 | Version v1
Journal article Metadata-only

Mechanism of rhythmic contractions induced by uranyl ion in the ileal longitudinal muscle of guinea-pig

Creators

  • 1. Pharmacological Institute, National Taiwan University, Taipei (Taiwan)

Description

The uranyl ion (UO22+) produces rhythmic contractions of the longitudinal muscle of the ileum, similar to those induced by repetitive transmural stimulation. Hexamethonium inhibited the action of UO22+, indicating a preganglionic site of action of UO22+ and interneurons possibly being involved in the ACh-releasing effect of UO22+. In addition, the action of UO22+ was enhanced by physostigmine but antagonized by atropine, ATP, adrenaline and morphine suggesting multiple sites of action of UO22+. The effects of Ba2+ were studied simultaneously in order to compare them with those of UO22+. (Auth.)

Additional details

Publishing Information

Journal Title
Eur. J. Pharmacol.
Journal Volume
113
Journal Issue
2
Series
Eur. J. Pharmacol.
Journal Page Range
199-204
ISSN
0014-2999
CODEN
EJPHA

INIS

Country of Publication
Netherlands
Country of Input or Organization
Netherlands
INIS RN
17012541
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
ACETYLCHOLINE; BARIUM; CONTRACTION; GUINEA PIGS; MUSCLES; SMALL INTESTINE; URANYL COMPOUNDS
Descriptors DEC
ACTINIDE COMPOUNDS; ALKALINE EARTH METALS; AMINES; ANIMALS; AUTONOMIC NERVOUS SYSTEM AGENT; BODY; DIGESTIVE SYSTEM; DRUGS; ELEMENTS; ESTERS; GASTROINTESTINAL TRACT; INTESTINES; MAMMALS; METALS; NEUROREGULATORS; ORGANIC COMPOUNDS; ORGANS; PARASYMPATHOMIMETICS; QUATERNARY COMPOUNDS; RODENTS; URANIUM COMPOUNDS; VERTEBRATES

Optional Information

Notes
25 refs.; 4 figs.