Published January 1975 | Version v1
Journal article Metadata-only

High-polymeric DNA efficiency under conditions of complex therapy of acute radiation sickness

Creators

  • 1. Nauchno-Issledovatel'skij Inst. Meditsinskoj Radiologii, Obninsk (USSR)

Description

Wistar line rats were gamma-irradiated by a Co60 source at a dose of 750 R and dose rate of 2500 R/min. The survival of the animals 30 days after the irradiation was 3.4%. Intraperitoneal administration of calf thymus DNA (3mg per 100 g body weight) brought the survival up to 21.3%. Treatment of irradiated animals with antibiotics, vitamins and amino acids carried out from 4th to 20th day after irradiation increased the initial survival up to 55.5%. DNA administration 24 hours after the irradiation together with the treatment with the indicated substances resulted in 89.9% survival of the animals

Additional details

Additional titles

Original title (Russian)
Эффективность высокополимерной ДНК в условиях комплексной терапии острой лучевой болезни

Publishing Information

Journal Title
Radiobiologiya
Journal Volume
15
Journal Issue
1
Series
Radiobiologiya.
Journal Page Range
46-50

INIS

Country of Publication
USSR
Country of Input or Organization
USSR
INIS RN
8286763
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
AMINO ACIDS; ANTIBIOTICS; COBALT 60; COMPARATIVE EVALUATIONS; DNA; GAMMA RADIATION; IRRADIATION; MORTALITY; POST-IRRADIATION THERAPY; RADIATION DOSES; RATS; SURVIVAL CURVES; VITAMINS
Descriptors DEC
ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CARBOXYLIC ACIDS; COBALT ISOTOPES; DRUGS; ELECTROMAGNETIC RADIATION; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTO; IONIZING RADIATIONS; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MAMMALS; MEDICINE; MINUTES LIVING RADIOISOTOPES; NUCLEI; NUCLEIC ACIDS; ODD-ODD NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; RADIATIONS; RADIOISOTOPES; RODENTS; THERAPY; VERTEBRATES; YEARS LIVING RADIOISOTOPES

Optional Information

Notes
For English translation see the journal Radiobiology.