Localization and scintigraphy vizualization of nanocomposite based on 99mTc-phosphate with Fe3O4 and KCl nanoparticles under radiofrequency hyperthermia on animal tumor Walker-256

A comparative experimental study of the localization under the influence of constant magnetic fields and local radio frequency moderate hyperthermia for the scintigraphic imaging of malignant Walker-256 carcinosarcoma tumors by conventional 99mTc-phosphate and nanocomposite based on 99mTc-phosphate with Fe3O4 and KCl is performed. It is shown that, after the introduction of conventional 99mTc-phosphate to animals from control group, no tumor is visualized. After the introduction of nanocomposite, we observed the accumulation and the visualization of radiopharmaceuticals in the tumor with diffusion-uneven distribution. Accumulation of nanocomposite in the projection of a tumor as compared with control animals increased by more than 2 times.