Published June 1991
| Version v1
Journal article
Free radical reactions of daunorubicin
Description
Daunorubicin is an antitumor antibiotic activated in vivo by reduction. Its mechanism of action involves DNA and topoisomerase attack, but side effects are cytotoxicity related to free radical formation. Therefore the mechanism of the one-electron reduction of the drug and the reactions of the daunorubicin transients towards compounds of biological interest have been studied by the methods of radiolysis, in order to provide possible explanations of the drug mechanism of action. Their relative importance in cellular conditions is discussed
Abstract (French)
La daunorubicine est un antibiotique antitumoral active in vivo par reduction. Au cours de cette reduction, des intermediaires radicalaires peuvent etre formes, et intervenir dans la toxicite de ce medicament. C'est pourquoi quelques reactions des formes transitoires de la daunorubicine avec des cibles d'interet biologique, ont ete etudiees par les methodes de la radiolyse. Leurs implications dans un milieu cellulaire sont discuteesAdditional details
Additional titles
- Original title (French)
- Reactions radicalaires de la daunorubicine
Publishing Information
- Journal Title
- Journal de Chimie Physique et de Physico-Chimie Biologique
- Journal Volume
- 88
- Journal Issue
- 6
- Series
- J. Chim. Phys. Phys.-Chim. Biol.
- Journal Page Range
- 897-905
- ISSN
- 0021-7689
- CODEN
- JCPBA
Conference
- Title
- 5. Meeting on Radiation Chemistry.
- Original Conference Title
- 5. Journees d'Etudes sur la Chimie sous Rayonnement
- Dates
- 1-6 Jul 1990.
- Place
- Sherbrooke, PQ (Canada).
INIS
- Country of Publication
- France
- Country of Input or Organization
- France
- INIS RN
- 23033960
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
- Resource subtype / Literary indicator
- Conference
- Descriptors DEI
- ANTIBIOTICS; GAMMA RADIATION; OXIDATION; RADICALS; RADIOLYSIS; REACTION INTERMEDIATES; REDUCTION
- Descriptors DEC
- ANTI-INFECTIVE AGENTS; CHEMICAL RADIATION EFFECTS; CHEMICAL REACTIONS; DECOMPOSITION; DRUGS; ELECTROMAGNETIC RADIATION; IONIZING RADIATIONS; ORGANIC COMPOUNDS; RADIATION EFFECTS; RADIATIONS