Published 1984 | Version v1
Journal article Metadata-only

Interest of the free T3 and T4 assays

Creators

  • 1. Hopital B, Centre Hospitalier Regional, 59 - Lille (France)

Description

This study has been carried out on 234 eu-hyper- or hypothyroid subjects for whom complete thyroid balances have been realized. These tests include the total T3 and T4 assays: the free T3 and free T4 assays, the TSH when necessary and, finally, the free thyroxine index calculation (IT4L). The fiability of the free hormones assays has been studied on various patients groups, all of them being clinically euthyroid but, either carrying various pathologies or taking medication modifying their thyroid hormone metabolism (Amiodarone). Results show: - the extremely good sensibility of the FT3 and FT4 assays concerning the diagnostic of hyperthyroid subjects, and, more over, reveal a very good specificity of the FT3 parameter; - that the basic TSH or stimulating test assays still remain reference tests in the diagnostic of hypothyroidy. The FT4 assay reveals a rather good specificity too; - the good stability of the FT3 parameter when applied on subjects carrying various pathologies or taking ''Amiodarone''. One notices that any diagnostic taken off from the alone FT4 assay would be, more or less, doubtfull

Abstract (French)

Cette etude porte sur 234 sujets eu-hyper ou hypothyroidiens pour lesquels ont ete realises des bilans thyroidiens complets incluant les dosages de T3 et T4 totales, de T3 et T4 libres, de TSH si necessaire, et le calcul de l'index de thyroxine libre (IT4L). La fiabilite des dosages des hormones libres a ete etudiee en particulier pour differents groupes de patients, tous cliniquement euthyroidiens, mais porteurs de pathologies diverses ou prenant des medications modifiant le metabolisme des hormones thyroidiennes (Amiodarone). Les resultats montrent: - l'excellente sensibilite des dosages (FT3 et FT4) dans le diagnostic de l'hyperthyroidie, couplee pour le parametre FT3 a une tres bonne specificite; - dans le diagnostic de l'hypothyroidie, les dosages de TSH en base ou au cours de tests de stimulation restent les examens de reference. Le dosage de FT4 revele une bonne specificite; - la bonne stabilite du parametre FT3 chez les sujets porteurs de pathologies diverses ou prenant de l'amiodarone; l'interpretation du seul dosage de FT4 peut etre delicate chez ces patients

Additional details

Additional titles

Original title (French)
Apport du dosage des formes libres des hormones thyroidiennes dans le diagnostic des thyropathies

Publishing Information

Journal Title
J. Biophys. Med. Nucl.
Journal Volume
8
Journal Issue
4
Series
J. Biophys. Med. Nucl.
Journal Page Range
227-230
ISSN
0399-0435

Conference

Title
Franco-Belgian meeting on nuclear medicine.
Dates
16 Mar 1984.
Place
Lille (France).

INIS

Country of Publication
France
Country of Input or Organization
France
INIS RN
16034700
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Resource subtype / Literary indicator
Conference
Descriptors DEI
DIAGNOSIS; HYPERTHYROIDISM; HYPOTHYROIDISM; RADIOIMMUNOASSAY; THYROXINE; TRIIODOTHYRONINE; TSH
Descriptors DEC
AMINO ACIDS; CARBOXYLIC ACIDS; DISEASES; ENDOCRINE DISEASES; HORMONES; ISOTOPE APPLICATIONS; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC IODINE COMPOUNDS; PEPTIDE HORMONES; PITUITARY HORMONES; THYROID HORMONES; TRACER TECHNIQUES