In-line X-ray phase contrast imaging: Initial simulation studies with breast-like phantom for mammography applications

The aim of this work is to demonstrate the use of a simulation platform for phase contrast imaging (PCI) in the field of x-ray imaging of breast. The software platform is based on a previously developed and validated in-house X-Ray Imaging Simulator used with software phantoms in x-ray imaging simulation studies. With this platform, a phantom has been modelled as a 4 cm thick slab filled with a polymethyl methacrylate material. The phantom also contained cylinder objects from water designed with various diameters, arranged at different planes. Planar projections images were simulated in phase contrast and absorption mode. The detectability of the cylindrical objects was quantitatively and visually assessed. This phantom has been manufactured and comparison with experimental data obtained at synchrotron facilities was accomplished. Image contrast of the cylinder objects was increased due to edge enhancement in both, the simulated and experimental images when PCI configuration geometry was used. (author)