Investigation into hydrogenolysis for preparation of tritium labelled compounds

Kinetics of hydrogenolysis of the series of bromine-substituted components of nucleic acids in the presence of palladium catalyst, is studied. A model for reaction of catalytic dehalogenation in solution is suggested. A mathematic description of the above model is given; rate constants for dehalogenation and palladium hydride formation at different temperatures (17-75 deg C) is given. Connection is found between kinetic parameters of hydrogenolysis and specific radioactivity of the dehalogenation product by tritium. The practical result of investigations performed is the increase of specific radioactivity of compounds prepared in the reaction of hydrogenolysis by tritium